City are 18 points clear of second-placed Liverpool after beating Chelsea 1-0 at the Etihad Stadium on Sunday and need just four wins from their final nine games to be sure of the title.
Lionel Messi came off the bench to inspire Barcelona to a 3-1 win over a dogged Leganes side on Sunday, creating one goal and scoring another to keep the Catalans five points clear at the top of La Liga.
Images from the European World Cup qualifiers played on Thursday
Top-class goals from Bernardo Silva and Sergio Aguero took Manchester City back to the top of the Premier League in a 2-0 win over Fulham at Craven Cottage on Saturday.
Photos from the Premier League matches played on Sunday
Danny Rose scored a second-half equaliser to cancel out James Milner's penalty as Tottenham Hotspur came from behind to draw 1-1 with Liverpool at White Hart Lane on Saturday.
Manchester City displayed champions' swagger as they roared clear at the top with a 5-0 trouncing of Burnley but it was drama which engulfed their neighbours Manchester United and Jose Mourinho that dominated the Premier League agenda on Saturday.
A summary of sports events and sports persons, who made news on Wednesday
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Philippe Coutinho inspired Liverpool to a comfortable 3-1 home win over Everton in the 228th Merseyside derby on Saturday to move provisionally up to third in the Premier League.
Floyd Mayweather Jr. cemented his place among the pantheon of boxing greats by improving to 48-0 with a unanimous decision over Manny Pacquiao on Saturday in a fight that lived up to its immense hype and price tag.
Liverpool had won each of their previous four home leagues games in which they conceded first and 12 minutes later they had turned another match on its head as Roberto Firmino's trickery set up Mane to give the hosts the lead at the second attempt.
Manchester City went 11 points clear with a record 14th consecutive Premier League win in an entertaining derby against Manchester United at Old Trafford.
IPL Action VIII: These players went unsold
World champions Germany drew 1-1 with Spain in a high tempo friendly on Friday as they launched their preparations for a title defence in Russia while their opponents had striker Diego Costa making his long-awaited comeback as a substitute.